I've a nephew, Mark, who graduated from OSU about 25 years ago. I recall chatting with him at Thanksgiving his freshman year. He related that some of his courses were held in auditoriums with as many as 500 students. The professor, he said, wasn't in the auditorium. Instead, he sat in his office, lecturing, and his visage was shown on TV screens positioned around the auditorium's perimeter.
I said, "How do you ask questions?"
Mark's reply, "You can't."
I attended O.U. in the early/mid 70's
My freshman Chemistry,Physics and Zoology classes all had several hundred students.
With rare exceptions,questions weren't allowed during lectures in Chemistry or Physics.
In Chemistry and Physics classes you had a once a week "recitation" class.
That was a group of about 20 students,with a grad assistant.
That was when you could ask questions and go over homework problems.
You could also ask questions in labs.
In Zoology there weren't many questions,so you could usually ask in class.
Most people "held" questions till lab.