If your D has had great strength conditioning throughout the year, they should be ok, if not, this has the potential to get ugly in the 2nd half.
S&C is actually one of the frequent points of angst around here, so it could get ugly. That being said, our secondary, in theory, is the strength of the defense. Our two best defensive players are our corners, who if healthy are pretty good. The issue comes with the D line. We have had a tough time against bigger, bruising O lines, and if the other team is able to push our D line around and establish the run early, the entire defense falls apart. We get a pretty good pass rush, but it hasn't been as good the second half of the season after we lost our best DE to injury. We start 2 true freshmen now (both have been really good so far, especially for true freshmen).
On O, our issues are (1) line play, and (2) our QB's attitude. We are young and smallish up front, and the group has not performed like we hoped at the beginning of the season (injuries to our 2 most experienced linemen in the first week didn't help). Again, if we are up against a bigger D Line, we usually look like crap. Against a smaller defensive front we look better. As for our QB, everyone agrees something isn't right, but no one can agree what it is--fear of injury, just not caring anymore, etc. Our base offense is a zone read type option, with lots of play action passing deep. However, if the bowl game is anything like the rest of the season, you will see frequent dives up the middle for 2 yards or less, regardless of down and distance, because our QB refuses to keep the ball. If your defensive front can get pressure early, you probably will get him frustrated and that will be that for the offense.
Also, bring the house on every punt. Our protection sucks, and our backup kicker is now our punter.