I'll be heading down today after work. Anything going on tonight? Looking like about a 6 hour drive?
If interested: Last year, the 110 shacked up in Maryville, TN and practiced at their HS field. I would think they might do the exact same thing this year. If so, Maryville is about 20 minutes south of Knoxville. The high school is on broadway and the field is easily visible from the road.
Other than that, the "strip" is the where you'll find the UT bars (Cumberland Avenue) just west of campus. If that's not your style, Calhoun's on the River is a great atmosphere. Walking distance from Neyland and right on the river. Great views.
The Old City is a good destination for local pubs. It's on the Northeast side of downtown. Market Square, downtown, also has a variety of cafes/pubs/coffee houses.