Absolutely no way to tell. The committee is supposed to keep you fairly close to home, but it also will not give you a bigger advantage than the higher seed you're up against.
The nice thing is five of the eight sites are easily driveable: Columbus, Pittsburgh, Louisville, Nashville and Greensboro. I would think the other three probably would be avoided for the MAC rep, but you never know: Omaha, Portland and Albuquerque.
I was looking at the sites and I agree that this is the most travel-friendly NCAA tournament for Ohio to get into in the last few years. There's no way in hell the committee puts an Ohio MAC team in Columbus (Ohio State would throw a hissy fit if they don't get the C-Bus venue but Ohio or Akron did), but Pittsburgh, Louisville or Nashville are really realistic drives for Ohio fans.
Ohio State is hosting the Columbus part of the tournament so it can't be seeded there. (If it was the Big Ten and not Ohio st. hosting they could though). They'll probably end up in Pittsburgh or Louisville.
Selfishly, I want Ohio seeded to the West Regional, so when I'm in Phoenix for an already planned trip on 3/24 I can watch them advance to the Final Four.