This loss is going to drop Akron from 37 to 57 in the RPI. It's going to hurt in the polls too. That would be Akron's only saving grace if they can make the MAC final and finish in the Top 25 of a poll. The magnitude of the Buffalo loss hurts them in that regard.
It will only drop their RPI to the mid-40's. They certainly still have at-large hopes but need to make the MAC Finals now.
Yahoo has them at 46 this morning; ESPN has them at 47. If this holds up even with a loss in the MAC championship game, they would likely be one of the last four in. If it comes down to Akron vs. another team, they usually look at what the team did during the last month of the season. The other teams around them are Notre Dame (5-3 since 2/1), Cincy (3-5), Oregon (5-3) and LaTech (8-0). So Akron (7-1) would be in pretty good shape.