Ohio has won just one midweek baseball games this year since MAC play started (in extras against Shawnee State), so maybe it's that the MAC is bad or maybe it's a lack of starting pitching depth for Ohio. I'd guess some of both, but it does appear the MAC is pretty bad. Other than Kent State, none of the MAC teams have performed very well out of conference. Kent State is the only MAC team with an RPI better than 177 (among less than 300 DI baseball teams).
Typically Smith goes with the "johnny whole-staff" approach to midweek games. He will use 7-9 different guys for the game. There are pros and cons with using this strategy, just a matter of each pitcher executing.
Looking back at the mid-week schedule, the teams we played are pretty decent and every game was competitive. Morehead st is a strong mid-major, you got Ohio st, Marshall twice, and Dayton. All respectable opponents but also winnable games.